1E8X
STRUCTURAL INSIGHTS INTO PHOSHOINOSITIDE 3-KINASE ENZYMATIC MECHANISM AND SIGNALLING
Replaces: 1QMMSummary for 1E8X
Entry DOI | 10.2210/pdb1e8x/pdb |
Related | 1E7U 1E7V 1E8W 1QMM |
Descriptor | PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT, ADENOSINE-5'-TRIPHOSPHATE, LUTETIUM (III) ION, ... (4 entities in total) |
Functional Keywords | phosphoinositide 3-kinase gamma, secondary messenger generation, pi3k, pi 3k |
Biological source | SUS SCROFA (WILD BOAR) |
Total number of polymer chains | 1 |
Total formula weight | 112034.44 |
Authors | Walker, E.H.,Perisic, O.,Ried, C.,Stephens, L.,Williams, R.L. (deposition date: 2000-10-03, release date: 2000-10-26, Last modification date: 2018-10-24) |
Primary citation | Walker, E.H.,Pacold, M.E.,Perisic, O.,Stephens, L.,Hawkins, P.T.,Whymann, M.P.,Williams, R.L. Structural Determinations of Phosphoinositide 3-Kinase Inhibition by Wortmannin, Ly294002, Quercetin, Myricetin and Staurosporine Mol.Cell, 6:909-, 2000 Cited by PubMed: 11090628DOI: 10.1016/S1097-2765(05)00089-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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