1E8X

STRUCTURAL INSIGHTS INTO PHOSHOINOSITIDE 3-KINASE ENZYMATIC MECHANISM AND SIGNALLING

Replaces:  1QMM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016301	molecular_function	kinase activity
A	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LU A3001

Chain	Residue
A	ASN951
A	ASP964
A	ATP3000

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LU A3002

Chain	Residue
A	HOH2080
A	HOH2171
A	LU3003
A	LU3004

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LU A3003

Chain	Residue
A	LU3002
A	LU3004
A	HOH2011
A	HOH2171

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LU A3004

Chain	Residue
A	HOH2011
A	HOH2081
A	HOH2175
A	LU3002
A	LU3003

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LU A3005

Chain	Residue
A	ASP836
A	ASP964
A	HOH2193
A	ATP3000

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LU A3006

Chain	Residue
A	ASP161
A	ASP164

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LU A3007

Chain	Residue
A	ASP358
A	ASP884
A	LU3008
A	LU3009

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LU A3008

Chain	Residue
A	ASP358
A	LU3007

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LU A3009

Chain	Residue
A	HOH2089
A	LU3007

---

site_id	BC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ATP A3000

Chain	Residue
A	MET804
A	SER806
A	LYS807
A	LYS808
A	PRO810
A	ILE831
A	LYS833
A	ASP836
A	TYR867
A	GLU880
A	VAL882
A	ASN951
A	MET953
A	ILE963
A	ASP964
A	HOH2253
A	LU3001
A	LU3005

---

Functional Information from PROSITE/UniProt

site_id	PS00915
Number of Residues	15
Details	PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKhg.DDLRQDmlilQ

Chain	Residue	Details
A	PHE832-GLN846

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site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVatFVLgIgDRHndN

Chain	Residue	Details
A	SER931-ASN951

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:11090628

Chain	Residue	Details
A	GLY829
A	LEU864
A	PHE961

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by PKA => ECO:0000250|UniProtKB:Q9JHG7

Chain	Residue	Details
A	THR1024

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000250|UniProtKB:P48736

Chain	Residue	Details
A	SER1101

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