1QJ7

Novel Covalent Active Site Thrombin Inhibitors

Summary for 1QJ7
Related1QJ1 1QJ6
DescriptorTHROMBIN, HIRUGEN, 6-CARBAMIMIDOYL-2-[5-(3-DIETHYLCARBAMOYL-PHENYL)-2-HYDROXY-INDAN-1-YL]-HEXANOIC ACID, ... (5 entities in total)
Functional Keywordshydrolase-hydrolase inhibitor complex, blood coagulation-inhibitor complex, proteinase, blood coagulation, trypsin like proteinase, protease-inhibitor complex, hydrolase- hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHOMO SAPIENS (HUMAN)
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Cellular locationSecreted, extracellular space: P00734 P00734
Total number of polymer chains3
Total formula weight35705.74
Authors
Jhoti, H.,Cleasby, A. (deposition date: 1999-06-22, release date: 2000-06-22, Last modification date: 2018-05-30)
Primary citationCleasby, A.,Jhoti, H.,Reid, S.,Thomas, P.,Weir, M.,Wonacott, A.
Crystal Structures of Thrombin Complexed to a Novel Series of Synthetic Inhibitors Containing a 5,5-Trans-Lactone Template
Biochemistry, 38:7969-, 1999
PubMed: 10387040
DOI: 110.1021/BI9830359
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation
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PDB entries from 2021-06-16