1Q3X

Crystal structure of the catalytic region of human MASP-2

1Q3X の概要

• エントリーDOI: 10.2210/pdb1q3x/pdb
• 分子名称: Mannan-binding lectin serine protease 2, SODIUM ION, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: complement, serine protease, modular structure, hinge bending, autoactivation, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: O00187
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72203.26

構造登録者

Harmat, V.,Gal, P.,Kardos, J.,Szilagyi, K.,Ambrus, G.,Naray-Szabo, G.,Zavodszky, P. (登録日: 2003-08-01, 公開日: 2004-08-03, 最終更新日: 2023-08-16)

• 主引用文献: Harmat, V.,Gal, P.,Kardos, J.,Szilagyi, K.,Ambrus, G.,Vegh, B.,Naray-Szabo, G.,Zavodsky, P.; The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions; J.Mol.Biol., 342:1533-1546, 2004; PubMed: 15364579; DOI: 10.1016/j.jmb.2004.07.014

実験手法

X-RAY DIFFRACTION (2.23 Å)