1Q2P

SHV-1 class A beta-lactamase complexed with penem WAY185229

Summary for 1Q2P

Entry DOI	10.2210/pdb1q2p/pdb
Related	1ONG 1ONH 1Q2Q 1SHV
Descriptor	beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, (6,7-DIHYDRO-5H-CYCLOPENTA[D]IMIDAZO[2,1-B]THIAZOL-2-YL]-4,7-DIHYDRO[1,4]THIAZEPINE-3,6-DICARBOXYLIC ACID, ... (4 entities in total)
Functional Keywords	hydrolase, inhibition, beta-lactam antibiotics, drug design
Biological source	Klebsiella pneumoniae
Total number of polymer chains	1
Total formula weight	30287.63
Authors	Nukaga, M.,Venkatesan, A.M.,Mansour, T.S.,Hujer, A.,Bonomo, R.A.,Knox, J.R. (deposition date: 2003-07-25, release date: 2004-09-14, Last modification date: 2023-08-16)
Primary citation	Venkatesan, A.M.,Gu, Y.,Dos Santos, O.,Abe, T.,Agarwal, A.,Yang, Y.,Petersen, P.J.,Weiss, W.J.,Mansour, T.S.,Nukaga, M.,Hujer, A.,Bonomo, R.A.,Knox, J.R. Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates J.Med.Chem., 47:6556-6568, 2004 Cited by PubMed: 15588091 DOI: 10.1021/jm049680x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation