1Q2P

SHV-1 class A beta-lactamase complexed with penem WAY185229

1Q2P の概要

• エントリーDOI: 10.2210/pdb1q2p/pdb
• 関連するPDBエントリー: 1ONG 1ONH 1Q2Q 1SHV
• 分子名称: beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, (6,7-DIHYDRO-5H-CYCLOPENTA[D]IMIDAZO[2,1-B]THIAZOL-2-YL]-4,7-DIHYDRO[1,4]THIAZEPINE-3,6-DICARBOXYLIC ACID, ... (4 entities in total)
• 機能のキーワード: hydrolase, inhibition, beta-lactam antibiotics, drug design
• 由来する生物種: Klebsiella pneumoniae
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30287.63

構造登録者

Nukaga, M.,Venkatesan, A.M.,Mansour, T.S.,Hujer, A.,Bonomo, R.A.,Knox, J.R. (登録日: 2003-07-25, 公開日: 2004-09-14, 最終更新日: 2023-08-16)

• 主引用文献: Venkatesan, A.M.,Gu, Y.,Dos Santos, O.,Abe, T.,Agarwal, A.,Yang, Y.,Petersen, P.J.,Weiss, W.J.,Mansour, T.S.,Nukaga, M.,Hujer, A.,Bonomo, R.A.,Knox, J.R.; Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates; J.Med.Chem., 47:6556-6568, 2004; PubMed: 15588091; DOI: 10.1021/jm049680x

実験手法

X-RAY DIFFRACTION (2 Å)