1Q0Q

Crystal structure of DXR in complex with the substrate 1-deoxy-D-xylulose-5-phosphate

Summary for 1Q0Q

• Entry DOI: 10.2210/pdb1q0q/pdb
• Related: 1Q0H 1Q0L
• Descriptor: 1-deoxy-D-xylulose 5-phosphate reductoisomerase, 1-DEOXY-D-XYLULOSE-5-PHOSPHATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• Functional Keywords: oxidoreductase
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 90728.82

Authors

Mac Sweeney, A.,Lange, R.,D'Arcy, A.,Douangamath, A.,Surivet, J.-P.,Oefner, C. (deposition date: 2003-07-17, release date: 2004-07-20, Last modification date: 2023-08-16)

• Primary citation: Mac Sweeney, A.,Lange, R.,Fernandes, R.P.,Schulz, H.,Dale, G.E.,Douangamath, A.,Proteau, P.J.,Oefner, C.; The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation.; J.Mol.Biol., 345:115-127, 2005; PubMed: 15567415; DOI: 10.1016/j.jmb.2004.10.030

Experimental method

X-RAY DIFFRACTION (1.9 Å)