1Q0Q

Crystal structure of DXR in complex with the substrate 1-deoxy-D-xylulose-5-phosphate

1Q0Q の概要

• エントリーDOI: 10.2210/pdb1q0q/pdb
• 関連するPDBエントリー: 1Q0H 1Q0L
• 分子名称: 1-deoxy-D-xylulose 5-phosphate reductoisomerase, 1-DEOXY-D-XYLULOSE-5-PHOSPHATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• 機能のキーワード: oxidoreductase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 90728.82

構造登録者

Mac Sweeney, A.,Lange, R.,D'Arcy, A.,Douangamath, A.,Surivet, J.-P.,Oefner, C. (登録日: 2003-07-17, 公開日: 2004-07-20, 最終更新日: 2023-08-16)

• 主引用文献: Mac Sweeney, A.,Lange, R.,Fernandes, R.P.,Schulz, H.,Dale, G.E.,Douangamath, A.,Proteau, P.J.,Oefner, C.; The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation.; J.Mol.Biol., 345:115-127, 2005; PubMed: 15567415; DOI: 10.1016/j.jmb.2004.10.030

実験手法

X-RAY DIFFRACTION (1.9 Å)