1PZM
Crystal structure of HGPRT-ase from Leishmania tarentolae in complex with GMP
Summary for 1PZM
| Entry DOI | 10.2210/pdb1pzm/pdb |
| Descriptor | hypoxanthine-guanine phosphoribosyltransferase, GUANOSINE-5'-MONOPHOSPHATE (3 entities in total) |
| Functional Keywords | transferase |
| Biological source | Leishmania tarentolae |
| Total number of polymer chains | 2 |
| Total formula weight | 48047.39 |
| Authors | Monzani, P.S.,Trapani, S.,Oliva, G.,Thiemann, O.H. (deposition date: 2003-07-11, release date: 2004-07-27, Last modification date: 2023-08-16) |
| Primary citation | Monzani, P.S.,Trapani, S.,Thiemann, O.H.,Oliva, G. Crystal structure of Leishmania tarentolae hypoxanthine-guanine phosphoribosyltransferase. Bmc Struct.Biol., 7:59-59, 2007 Cited by PubMed Abstract: Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (EC 2.4.2.8) is a central enzyme in the purine recycling pathway. Parasitic protozoa of the order Kinetoplastida cannot synthesize purines de novo and use the salvage pathway to synthesize purine bases, making this an attractive target for antiparasitic drug design. PubMed: 17894860DOI: 10.1186/1472-6807-7-59 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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