1PZM

Crystal structure of HGPRT-ase from Leishmania tarentolae in complex with GMP

1PZM の概要

• エントリーDOI: 10.2210/pdb1pzm/pdb
• 分子名称: hypoxanthine-guanine phosphoribosyltransferase, GUANOSINE-5'-MONOPHOSPHATE (3 entities in total)
• 機能のキーワード: transferase
• 由来する生物種: Leishmania tarentolae
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 48047.39

構造登録者

Monzani, P.S.,Trapani, S.,Oliva, G.,Thiemann, O.H. (登録日: 2003-07-11, 公開日: 2004-07-27, 最終更新日: 2023-08-16)

主引用文献

Monzani, P.S.,Trapani, S.,Thiemann, O.H.,Oliva, G.
Crystal structure of Leishmania tarentolae hypoxanthine-guanine phosphoribosyltransferase.
Bmc Struct.Biol., 7:59-59, 2007

PubMed Abstract: Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (EC 2.4.2.8) is a central enzyme in the purine recycling pathway. Parasitic protozoa of the order Kinetoplastida cannot synthesize purines de novo and use the salvage pathway to synthesize purine bases, making this an attractive target for antiparasitic drug design.

PubMed: 17894860
DOI: 10.1186/1472-6807-7-59

実験手法

X-RAY DIFFRACTION (2.1 Å)