1PVN
The crystal structure of the complex between IMP dehydrogenase catalytic domain and a transition state analogue MZP
Replaces: 1MWFSummary for 1PVN
Entry DOI | 10.2210/pdb1pvn/pdb |
Related | 1LRT |
Descriptor | Inosine-5'-monophosphate dehydrogenase, POTASSIUM ION, 4-CARBAMOYL-1-BETA-D-RIBOFURANOSYL-IMIDAZOLIUM-5-OLATE-5'-PHOSPHATE, ... (5 entities in total) |
Functional Keywords | transition state analogue, imp dehydrogenase, mizoribine 5'-monophosphate, distal flap, general base, drug selectivity, oxidoreductase |
Biological source | Tritrichomonas foetus More |
Cellular location | Cytoplasm : P50097 |
Total number of polymer chains | 4 |
Total formula weight | 167246.02 |
Authors | Gan, L.,Seyedsayamdost, M.,Shuto, S.,Matsuda, A.,Petsko, G.A.,Hedstrom, L. (deposition date: 2003-06-27, release date: 2003-07-22, Last modification date: 2023-08-16) |
Primary citation | Gan, L.,Seyedsayamdost, M.,Shuto, S.,Matsuda, A.,Petsko, G.A.,Hedstrom, L. The Immunosuppressive Agent Mizoribine Monophosphate Forms a Transition State Analogue Complex with Inosine Monophosphate Dehydrogenase Biochemistry, 42:857-863, 2003 Cited by PubMed: 12549902DOI: 10.1021/bi0271401 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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