1PVN

The crystal structure of the complex between IMP dehydrogenase catalytic domain and a transition state analogue MZP

Replaces:  1MWF

Summary for 1PVN

• Entry DOI: 10.2210/pdb1pvn/pdb
• Related: 1LRT
• Descriptor: Inosine-5'-monophosphate dehydrogenase, POTASSIUM ION, 4-CARBAMOYL-1-BETA-D-RIBOFURANOSYL-IMIDAZOLIUM-5-OLATE-5'-PHOSPHATE, ... (5 entities in total)
• Functional Keywords: transition state analogue, imp dehydrogenase, mizoribine 5'-monophosphate, distal flap, general base, drug selectivity, oxidoreductase
• Biological source: Tritrichomonas foetus; More
• Cellular location: Cytoplasm : P50097
• Total number of polymer chains: 4
• Total formula weight: 167246.02

Authors

Gan, L.,Seyedsayamdost, M.,Shuto, S.,Matsuda, A.,Petsko, G.A.,Hedstrom, L. (deposition date: 2003-06-27, release date: 2003-07-22, Last modification date: 2023-08-16)

• Primary citation: Gan, L.,Seyedsayamdost, M.,Shuto, S.,Matsuda, A.,Petsko, G.A.,Hedstrom, L.; The Immunosuppressive Agent Mizoribine Monophosphate Forms a Transition State Analogue Complex with Inosine Monophosphate Dehydrogenase; Biochemistry, 42:857-863, 2003; PubMed: 12549902; DOI: 10.1021/bi0271401

Experimental method

X-RAY DIFFRACTION (2 Å)