1PVN

The crystal structure of the complex between IMP dehydrogenase catalytic domain and a transition state analogue MZP

「1MWF」から置き換えられました

1PVN の概要

• エントリーDOI: 10.2210/pdb1pvn/pdb
• 関連するPDBエントリー: 1LRT
• 分子名称: Inosine-5'-monophosphate dehydrogenase, POTASSIUM ION, 4-CARBAMOYL-1-BETA-D-RIBOFURANOSYL-IMIDAZOLIUM-5-OLATE-5'-PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: transition state analogue, imp dehydrogenase, mizoribine 5'-monophosphate, distal flap, general base, drug selectivity, oxidoreductase
• 由来する生物種: Tritrichomonas foetus; 詳細
• 細胞内の位置: Cytoplasm : P50097
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 167246.02

構造登録者

Gan, L.,Seyedsayamdost, M.,Shuto, S.,Matsuda, A.,Petsko, G.A.,Hedstrom, L. (登録日: 2003-06-27, 公開日: 2003-07-22, 最終更新日: 2023-08-16)

• 主引用文献: Gan, L.,Seyedsayamdost, M.,Shuto, S.,Matsuda, A.,Petsko, G.A.,Hedstrom, L.; The Immunosuppressive Agent Mizoribine Monophosphate Forms a Transition State Analogue Complex with Inosine Monophosphate Dehydrogenase; Biochemistry, 42:857-863, 2003; PubMed: 12549902; DOI: 10.1021/bi0271401

実験手法

X-RAY DIFFRACTION (2 Å)