1PL0
Crystal structure of human ATIC in complex with folate-based inhibitor, BW2315U89UC
Summary for 1PL0
Entry DOI | 10.2210/pdb1pl0/pdb |
Related | 1P4R 1PKX |
Descriptor | Bifunctional purine biosynthesis protein PURH, POTASSIUM ION, XANTHOSINE-5'-MONOPHOSPHATE, ... (6 entities in total) |
Functional Keywords | human atic, aicar, aicar transformylase, imp cyclohydrolase, xanthosine monophosphate, folate-based inhibitor, bw2315u89uc, transferase, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 261655.24 |
Authors | Cheong, C.G.,Greasley, S.E.,Horton, P.A.,Beardsley, G.P.,Wilson, I.A. (deposition date: 2003-06-06, release date: 2004-04-27, Last modification date: 2023-08-16) |
Primary citation | Cheong, C.G.,Wolan, D.W.,Greasley, S.E.,Horton, P.A.,Beardsley, G.P.,Wilson, I.A. Crystal Structures of Human Bifunctional Enzyme Aminoimidazole-4-carboxamide Ribonucleotide Transformylase/IMP Cyclohydrolase in Complex with Potent Sulfonyl-containing Antifolates. J.Biol.Chem., 279:18034-18045, 2004 Cited by PubMed: 14966129DOI: 10.1074/jbc.M313691200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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