1PL0

Crystal structure of human ATIC in complex with folate-based inhibitor, BW2315U89UC

1PL0 の概要

• エントリーDOI: 10.2210/pdb1pl0/pdb
• 関連するPDBエントリー: 1P4R 1PKX
• 分子名称: Bifunctional purine biosynthesis protein PURH, POTASSIUM ION, XANTHOSINE-5'-MONOPHOSPHATE, ... (6 entities in total)
• 機能のキーワード: human atic, aicar, aicar transformylase, imp cyclohydrolase, xanthosine monophosphate, folate-based inhibitor, bw2315u89uc, transferase, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 261655.24

構造登録者

Cheong, C.G.,Greasley, S.E.,Horton, P.A.,Beardsley, G.P.,Wilson, I.A. (登録日: 2003-06-06, 公開日: 2004-04-27, 最終更新日: 2023-08-16)

• 主引用文献: Cheong, C.G.,Wolan, D.W.,Greasley, S.E.,Horton, P.A.,Beardsley, G.P.,Wilson, I.A.; Crystal Structures of Human Bifunctional Enzyme Aminoimidazole-4-carboxamide Ribonucleotide Transformylase/IMP Cyclohydrolase in Complex with Potent Sulfonyl-containing Antifolates.; J.Biol.Chem., 279:18034-18045, 2004; PubMed: 14966129; DOI: 10.1074/jbc.M313691200

実験手法

X-RAY DIFFRACTION (2.6 Å)