The co-crystal structure of CysG, the multifunctional methyltransferase/dehydrogenase/ferrochelatase for siroheme synthesis, in complex with it NAD cofactor

Summary for 1PJS

Related1PJQ 1PJT
DescriptorSiroheme synthase, S-ADENOSYL-L-HOMOCYSTEINE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (6 entities in total)
Functional Keywordsrossmann fold, nucleotide binding motif, sah, sam, nad, phosphoserine, transferase-oxidoreductase-lyase complex, transferase/oxidoreductase/lyase
Biological sourceSalmonella typhimurium
Total number of polymer chains2
Total molecular weight103063.94
Stroupe, M.E.,Leech, H.K.,Daniels, D.S.,Warren, M.J.,Getzoff, E.D. (deposition date: 2003-06-03, release date: 2003-12-02, Last modification date: 2014-11-12)
Primary citation
Stroupe, M.E.,Leech, H.K.,Daniels, D.S.,Warren, M.J.,Getzoff, E.D.
CysG structure reveals tetrapyrrole-binding features and novel regulation of siroheme biosynthesis.
Nat.Struct.Biol., 10:1064-1073, 2003
PubMed: 14595395 (PDB entries with the same primary citation)
DOI: 10.1038/nsb1007
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.279241.6%11.1%3.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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