1PJP

THE 2.2 A CRYSTAL STRUCTURE OF HUMAN CHYMASE IN COMPLEX WITH SUCCINYL-ALA-ALA-PRO-PHE-CHLOROMETHYLKETONE

Summary for 1PJP

• Entry DOI: 10.2210/pdb1pjp/pdb
• Related PRD ID: PRD_000381
• Descriptor: Chymase, SUCCINYL-ALA-ALA-PRO-PHE-CHLOROMETHYLKETONE INHIBITOR, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: human chymase, serine proteinase, dipeptidyl carboxypeptidase, angiotensin, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 26038.70

Authors

Pereira, P.J.B.,Wang, Z.M.,Rubin, H.,Huber, R.,Bode, W.,Schechter, N.M.,Strobl, S. (deposition date: 1998-09-07, release date: 1999-03-02, Last modification date: 2024-04-24)

• Primary citation: Pereira, P.J.,Wang, Z.M.,Rubin, H.,Huber, R.,Bode, W.,Schechter, N.M.,Strobl, S.; The 2.2 A crystal structure of human chymase in complex with succinyl-Ala-Ala-Pro-Phe-chloromethylketone: structural explanation for its dipeptidyl carboxypeptidase specificity.; J.Mol.Biol., 286:163-173, 1999; PubMed: 9931257; DOI: 10.1006/jmbi.1998.2462

Experimental method

X-RAY DIFFRACTION (2.2 Å)