1PGR

2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR

1PGR の概要

• エントリーDOI: 10.2210/pdb1pgr/pdb
• 分子名称: PROTEIN (GRANULOCYTE COLONY-STIMULATING FACTOR), PROTEIN (G-CSF RECEPTOR) (2 entities in total)
• 機能のキーワード: class1 cytokine, hematopoietic receptor, signal transduction, cytokine
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P09919; Membrane; Single-pass type I membrane protein: P40223
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 173108.10

構造登録者

Aritomi, M.,Kunishima, N.,Okamoto, T.,Kuroki, R.,Ota, Y.,Morikawa, K. (登録日: 1999-03-08, 公開日: 2000-03-08, 最終更新日: 2024-11-13)

主引用文献

Aritomi, M.,Kunishima, N.,Okamoto, T.,Kuroki, R.,Ota, Y.,Morikawa, K.
Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme.
Nature, 401:713-717, 1999

PubMed Abstract: Granulocyte colony-stimulating factor (GCSF) is the principal growth factor regulating the maturation, proliferation and differentiation of the precursor cells of neutrophilic granulocytes and is used to treat neutropenia. GCSF is a member of the long-chain subtype of the class 1 cytokine superfamily, which includes growth hormone, erythropoietin, interleukin 6 and oncostatin M. Here we have determined the crystal structure of GCSF complexed to the BN-BC domains, the principal ligand-binding region of the GCSF receptor (GCSFR). The two receptor domains form a complex in a 2:2 ratio with the ligand, with a non-crystallographic pseudo-twofold axis through primarily the interdomain region and secondarily the BC domain. This structural view of a gp130-type receptor-ligand complex presents a new molecular basis for cytokine-receptor recognition.

PubMed: 10537111
DOI: 10.1038/44394

実験手法

X-RAY DIFFRACTION (3.5 Å)