1P9M

Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex

1P9M の概要

• エントリーDOI: 10.2210/pdb1p9m/pdb
• 分子名称: Interleukin-6 receptor beta chain, Interleukin-6, Interleukin-6 receptor alpha chain (3 entities in total)
• 機能のキーワード: ig domain, four helix bundle, cytokine, interleukin-6, gp130, signaling protein-cytokine complex, signaling protein/cytokine
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P40189; Secreted: P05231; Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P08887
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 78253.48

構造登録者

Boulanger, M.J.,Chow, D.C.,Brevnova, E.E.,Garcia, K.C. (登録日: 2003-05-12, 公開日: 2003-07-01, 最終更新日: 2023-08-16)

• 主引用文献: Boulanger, M.J.,Chow, D.C.,Brevnova, E.E.,Garcia, K.C.; Hexameric Structure and Assembly of the Interleukin-6/IL-6 alpha-Receptor/gp130 Complex; Science, 300:2101-2104, 2003; PubMed: 12829785; DOI: 10.1126/science.1083901

実験手法

X-RAY DIFFRACTION (3.65 Å)