1P93
CRYSTAL STRUCTURE OF THE AGONIST FORM OF GLUCOCORTICOID RECEPTOR
Summary for 1P93
Entry DOI | 10.2210/pdb1p93/pdb |
Related | 1NHZ |
Descriptor | Glucocorticoid receptor, Nuclear receptor coactivator 2, DEXAMETHASONE (3 entities in total) |
Functional Keywords | protein-ligand complex, anti parallel alpha helix sandwich, hormone receptor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 8 |
Total formula weight | 136105.16 |
Authors | Kauppi, B.,Jakob, C.,Farnegardh, M.,Yang, J.,Ahola, H.,Alarcon, M.,Calles, K.,Engstrom, O.,Harlan, J.,Muchmore, S.,Ramqvist, A.-K.,Thorell, S.,Ohman, L.,Greer, J.,Gustafsson, J.-A.,Carlstedt-Duke, J.,Carlquist, M. (deposition date: 2003-05-09, release date: 2003-07-08, Last modification date: 2023-08-16) |
Primary citation | Kauppi, B.,Jakob, C.,Farnegardh, M.,Yang, J.,Ahola, H.,Alarcon, M.,Calles, K.,Engstrom, O.,Harlan, J.,Muchmore, S.,Ramqvist, A.-K.,Thorell, S.,Ohman, L.,Greer, J.,Gustafsson, J.-A.,Carlstedt-Duke, J.,Carlquist, M. The Three-dimensional Structures of Antagonistic and Agonistic Forms of the Glucocorticoid Receptor Ligand-binding Domain: RU-486 INDUCES A TRANSCONFORMATION THAT LEADS TO ACTIVE ANTAGONISM. J.Biol.Chem., 278:22748-22754, 2003 Cited by PubMed: 12686538DOI: 10.1074/jbc.M212711200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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