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1P93

CRYSTAL STRUCTURE OF THE AGONIST FORM OF GLUCOCORTICOID RECEPTOR

Summary for 1P93
Entry DOI10.2210/pdb1p93/pdb
Related1NHZ
DescriptorGlucocorticoid receptor, Nuclear receptor coactivator 2, DEXAMETHASONE (3 entities in total)
Functional Keywordsprotein-ligand complex, anti parallel alpha helix sandwich, hormone receptor
Biological sourceHomo sapiens (human)
More
Total number of polymer chains8
Total formula weight136105.16
Authors
Primary citationKauppi, B.,Jakob, C.,Farnegardh, M.,Yang, J.,Ahola, H.,Alarcon, M.,Calles, K.,Engstrom, O.,Harlan, J.,Muchmore, S.,Ramqvist, A.-K.,Thorell, S.,Ohman, L.,Greer, J.,Gustafsson, J.-A.,Carlstedt-Duke, J.,Carlquist, M.
The Three-dimensional Structures of Antagonistic and Agonistic Forms of the Glucocorticoid Receptor Ligand-binding Domain: RU-486 INDUCES A TRANSCONFORMATION THAT LEADS TO ACTIVE ANTAGONISM.
J.Biol.Chem., 278:22748-22754, 2003
Cited by
PubMed: 12686538
DOI: 10.1074/jbc.M212711200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

217705

数据于2024-03-27公开中

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