1P93
CRYSTAL STRUCTURE OF THE AGONIST FORM OF GLUCOCORTICOID RECEPTOR
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE DEX A 1999 |
| Chain | Residue |
| A | MET560 |
| A | GLN642 |
| A | MET646 |
| A | TYR735 |
| A | CYS736 |
| A | THR739 |
| A | ILE747 |
| A | LEU563 |
| A | ASN564 |
| A | GLY567 |
| A | GLN570 |
| A | MET601 |
| A | MET604 |
| A | ARG611 |
| A | PHE623 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE DEX B 2999 |
| Chain | Residue |
| B | MET560 |
| B | ASN564 |
| B | GLY567 |
| B | GLN570 |
| B | MET601 |
| B | MET604 |
| B | ARG611 |
| B | PHE623 |
| B | GLN642 |
| B | MET646 |
| B | TYR735 |
| B | CYS736 |
| B | THR739 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE DEX C 3999 |
| Chain | Residue |
| C | MET560 |
| C | LEU563 |
| C | ASN564 |
| C | GLY567 |
| C | GLN570 |
| C | MET601 |
| C | ARG611 |
| C | PHE623 |
| C | GLN642 |
| C | MET646 |
| C | LEU732 |
| C | TYR735 |
| C | CYS736 |
| C | THR739 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE DEX D 4999 |
| Chain | Residue |
| D | MET560 |
| D | LEU563 |
| D | ASN564 |
| D | GLY567 |
| D | GLN570 |
| D | MET601 |
| D | MET604 |
| D | LEU608 |
| D | ARG611 |
| D | PHE623 |
| D | GLN642 |
| D | MET646 |
| D | TYR735 |
| D | CYS736 |
| D | THR739 |
| D | ILE747 |
| D | PHE749 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 660 |
| Details | Region: {"description":"Interaction with CRY1","evidences":[{"source":"PubMed","id":"22170608","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"12144530","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Motif: {"description":"LXXLL motif 3"} |
| Chain | Residue | Details |
