1P93
CRYSTAL STRUCTURE OF THE AGONIST FORM OF GLUCOCORTICOID RECEPTOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, B, C, D) | Glucocorticoid receptor | polymer | 280 | 32155.1 | 4 | UniProt (P04150) Pfam (PF00104) | Homo sapiens (human) | GR |
| 2 | B, D, F, H (E, F, G, H) | Nuclear receptor coactivator 2 | polymer | 12 | 1478.8 | 4 | UniProt (Q15596) | NCoA-2, Transcriptional intermediary factor 2 | |
| 3 | I, J, K, L (A, B, C, D) | DEXAMETHASONE | non-polymer | 392.5 | 4 | Chemie (DEX) |
Sequence modifications
A, B, C, D: 500 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Gly 498 | - | cloning artifact |
| Ser 499 | - | cloning artifact |
| Asp 517 | Asn 517 | engineered mutation |
| Ser 602 | Phe 602 | engineered mutation |
| Asp 638 | Cys 638 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 134535.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1569.8 | |
| All* | Total formula weight | 136105.2 |
