1P7K

Crystal structure of an anti-ssDNA antigen-binding fragment (Fab) bound to 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid (HEPES)

Summary for 1P7K

• Entry DOI: 10.2210/pdb1p7k/pdb
• Related: 1I8M
• Descriptor: antibody light chain FAB, antibody heavy chain FAB, SULFATE ION, ... (8 entities in total)
• Functional Keywords: fab, antibody, anti-dna antibody, autoantibody, lupus, hepes, immune system
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 4
• Total formula weight: 99518.46

Authors

Schuermann, J.P.,Henzl, M.T.,Deutscher, S.L.,Tanner, J.J. (deposition date: 2003-05-02, release date: 2004-05-11, Last modification date: 2023-08-16)

• Primary citation: Schuermann, J.P.,Henzl, M.T.,Deutscher, S.L.,Tanner, J.J.; Structure of an anti-DNA fab complexed with a non-DNA ligand provides insights into cross-reactivity and molecular mimicry.; Proteins, 57:269-278, 2004; PubMed: 15340914; DOI: 10.1002/prot.20200

Experimental method

X-RAY DIFFRACTION (1.75 Å)