1P18

Hypoxanthine Phosphoribosyltransferase from Trypanosoma cruzi, K68R mutant, ternary substrates complex

Summary for 1P18

Entry DOI	10.2210/pdb1p18/pdb
Related	1p17 1p19 1tc1 1tc2
Descriptor	hypoxanthine phosphoribosyltransferase, MAGNESIUM ION, 7-HYDROXY-PYRAZOLO[4,3-D]PYRIMIDINE, ... (5 entities in total)
Functional Keywords	transferase, glycosyltransferase, phosphoribosyltransferase, nucleotide metabolism, purine salvage, ternary complex
Biological source	Trypanosoma cruzi
Total number of polymer chains	2
Total formula weight	52396.42
Authors	Canyuk, B.,Eakin, A.E.,Craig III, S.P. (deposition date: 2003-04-11, release date: 2004-05-18, Last modification date: 2024-02-14)
Primary citation	Canyuk, B.,Medrano, F.J.,Wenck, M.A.,Focia, P.J.,Eakin, A.E.,Craig III, S.P. Interactions at the dimer interface influence the relative efficiencies for purine nucleotide synthesis and pyrophosphorolysis in a phosphoribosyltransferase J.Mol.Biol., 335:905-921, 2004 Cited by PubMed: 14698288 DOI: 10.1016/j.jmb.2003.11.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation