1P18
Hypoxanthine Phosphoribosyltransferase from Trypanosoma cruzi, K68R mutant, ternary substrates complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | hypoxanthine phosphoribosyltransferase | polymer | 221 | 25623.4 | 2 | UniProt (Q27796) Pfam (PF00156) UniProt (by SIFTS) (Q4DRC4) | Trypanosoma cruzi | |
| 2 | C, D, G, H (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 3 | E, I (A, B) | 7-HYDROXY-PYRAZOLO[4,3-D]PYRIMIDINE | non-polymer | 136.1 | 2 | Chemie (7HP) | |||
| 4 | F, J (A, B) | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose | non-polymer | 390.1 | 2 | Chemie (PRP) | |||
| 5 | K, L (A, B) | water | water | 18.0 | 109 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 221 (UniProt: Q27796)
| PDB | External Database | Details |
|---|---|---|
| Lys 23 | Met 23 | SEE REMARK 999 |
| Arg 52 | Lys 52 | engineered mutation |
| Cys 66 | Ser 66 | SEE REMARK 999 |
| Leu 86 | Val 86 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 51246.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1149.6 | |
| All* | Total formula weight | 52396.4 |
