1OZ0

CRYSTAL STRUCTURE OF THE HOMODIMERIC BIFUNCTIONAL TRANSFORMYLASE AND CYCLOHYDROLASE ENZYME AVIAN ATIC IN COMPLEX WITH A MULTISUBSTRATE ADDUCT INHIBITOR BETA-DADF.

1OZ0 の概要

• エントリーDOI: 10.2210/pdb1oz0/pdb
• 関連するPDBエントリー: 1G8M 1M9N
• 分子名称: Bifunctional purine biosynthesis protein PURH, POTASSIUM ION, PHOSPHATE ION, ... (5 entities in total)
• 機能のキーワード: homodimer, 2 functional domains, impch domain = alpha/beta/alpha, aicar tfase = 2 alpha/beta/alpha domains, 1 alpha + beta domain, transferase, hydrolase
• 由来する生物種: Gallus gallus (chicken)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 135237.58

構造登録者

Wolan, D.W.,Greasley, S.E.,Wall, M.J.,Benkovic, S.J.,Wilson, I.A. (登録日: 2003-04-07, 公開日: 2003-09-30, 最終更新日: 2023-08-16)

• 主引用文献: Wolan, D.W.,Greasley, S.E.,Wall, M.J.,Benkovic, S.J.,Wilson, I.A.; Structure of Avian AICAR Transformylase with a Multisubstrate Adduct Inhibitor beta-DADF Identifies the Folate Binding Site.; Biochemistry, 42:10904-10914, 2003; PubMed: 12974624; DOI: 10.1021/bi030106h

実験手法

X-RAY DIFFRACTION (2.5 Å)