1OUY

The structure of p38 alpha in complex with a dihydropyrido-pyrimidine inhibitor

1OUY の概要

• エントリーDOI: 10.2210/pdb1ouy/pdb
• 関連するPDBエントリー: 1M7Q 1OUK 1OVE
• 分子名称: Mitogen-activated protein kinase 14, 1-(2,6-DICHLOROPHENYL)-6-[(2,4-DIFLUOROPHENYL)SULFANYL]-7-(1,2,3,6-TETRAHYDRO-4-PYRIDINYL)-3,4-DIHYDROPYRIDO[3,2-D]PYRIMIDIN-2(1H)-ONE (3 entities in total)
• 機能のキーワード: map kinase, hydrophobic pocket, kinase domain, atp binding domain, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : Q16539
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42518.33

構造登録者

Fitzgerald, C.E.,Patel, S.B.,Becker, J.W.,Cameron, P.M.,Zaller, D.,Pikounis, V.B.,O'Keefe, S.J.,Scapin, G. (登録日: 2003-03-25, 公開日: 2003-09-02, 最終更新日: 2023-08-16)

• 主引用文献: Fitzgerald, C.E.,Patel, S.B.,Becker, J.W.,Cameron, P.M.,Zaller, D.,Pikounis, V.B.,O'Keefe, S.J.,Scapin, G.; Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity; Nat.Struct.Biol., 10:764-769, 2003; PubMed: 12897767; DOI: 10.1038/nsb949

実験手法

X-RAY DIFFRACTION (2.5 Å)