1OT7
Structural Basis for 3-deoxy-CDCA Binding and Activation of FXR
Summary for 1OT7
Entry DOI | 10.2210/pdb1ot7/pdb |
Related | 1OSV |
Descriptor | Bile Acid Receptor, dodecamer peptide fragment of RPGR-interacting protein 1, 6-ETHYL-CHENODEOXYCHOLIC ACID, ... (5 entities in total) |
Functional Keywords | bile acid, nuclear receptor, coactivator, ligand binding domain, fxr, hormone-growth factor receptor complex, hormone/growth factor receptor |
Biological source | Rattus norvegicus (Norway rat) More |
Cellular location | Nucleus (Probable): Q62735 |
Total number of polymer chains | 5 |
Total formula weight | 58712.76 |
Authors | Mi, L.Z.,Devarakonda, S.,Harp, J.M.,Han, Q.,Pellicciari, R.,Willson, T.M.,Khorasanizadeh, S.,Rastinejad, F. (deposition date: 2003-03-21, release date: 2004-03-23, Last modification date: 2024-04-03) |
Primary citation | Mi, L.Z.,Devarakonda, S.,Harp, J.M.,Han, Q.,Pellicciari, R.,Willson, T.M.,Khorasanizadeh, S.,Rastinejad, F. Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR Mol.Cell, 11:1093-1100, 2003 Cited by PubMed: 12718893DOI: 10.1016/S1097-2765(03)00112-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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