1OSV

STRUCTURAL BASIS FOR BILE ACID BINDING AND ACTIVATION OF THE NUCLEAR RECEPTOR FXR

Summary for 1OSV

Entry DOI	10.2210/pdb1osv/pdb
Descriptor	Bile acid receptor, Nuclear receptor coactivator 2, 6-ETHYL-CHENODEOXYCHOLIC ACID, ... (4 entities in total)
Functional Keywords	lbd, bile acid, coactivator, nuclear receptor, dna binding protein
Biological source	Rattus norvegicus (Norway rat) More
Cellular location	Nucleus (Probable): Q62735 Nucleus: Q61026
Total number of polymer chains	5
Total formula weight	58937.02
Authors	Mi, L.Z.,Devarakonda, S.,Harp, J.M.,Han, Q.,Pellicciari, R.,Willson, T.M.,Khorasanizadeh, S.,Rastinejad, F. (deposition date: 2003-03-20, release date: 2004-03-23, Last modification date: 2024-02-14)
Primary citation	Mi, L.Z.,Devarakonda, S.,Harp, J.M.,Han, Q.,Pellicciari, R.,Willson, T.M.,Khorasanizadeh, S.,Rastinejad, F. Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR Mol.Cell, 11:1093-1100, 2003 Cited by PubMed: 12718893 DOI: 10.1016/S1097-2765(03)00112-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation