1OSH

A Chemical, Genetic, and Structural Analysis of the nuclear bile acid receptor FXR

1OSH の概要

• エントリーDOI: 10.2210/pdb1osh/pdb
• 分子名称: Bile acid receptor, METHYL 3-{3-[(CYCLOHEXYLCARBONYL){[4'-(DIMETHYLAMINO)BIPHENYL-4-YL]METHYL}AMINO]PHENYL}ACRYLATE (3 entities in total)
• 機能のキーワード: nuclear receptor, ligand binding domain, transcription
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus (Probable): Q96RI1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27583.72

構造登録者

Downes, M.,Verdecia, M.A.,Roecker, A.J.,Hughes, R.,Hogenesch, J.B.,Kast-Woelbern, H.R.,Bowman, M.E.,Ferrer, J.-L.,Anisfeld, A.M.,Edwards, P.A.,Rosenfeld, J.M.,Alvarez, J.G.A.,Noel, J.P.,Nicolaou, K.C.,Evans, R.M. (登録日: 2003-03-19, 公開日: 2003-09-23, 最終更新日: 2024-02-14)

• 主引用文献: Downes, M.,Verdecia, M.A.,Roecker, A.J.,Hughes, R.,Hogenesch, J.B.,Kast-Woelbern, H.R.,Bowman, M.E.,Ferrer, J.-L.,Anisfeld, A.M.,Edwards, P.A.,Rosenfeld, J.M.,Alvarez, J.G.,Noel, J.P.,Nicolaou, K.C.,Evans, R.M.; A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR; Mol.Cell, 11:1079-1092, 2003; PubMed: 12718892; DOI: 10.1016/S1097-2765(03)00104-7

実験手法

X-RAY DIFFRACTION (1.8 Å)