1OS5

Crystal structure of HCV NS5B RNA polymerase complexed with a novel non-competitive inhibitor.

1OS5 の概要

• エントリーDOI: 10.2210/pdb1os5/pdb
• 分子名称: Hepatitis C virus NS5B RNA polymerase, 3-(4-AMINO-2-TERT-BUTYL-5-METHYL-PHENYLSULFANYL)-6-CYCLOPENTYL-4-HYDROXY-6-[2-(4-HYDROXY-PHENYL)-ETHYL]-5,6-DIHYDRO-PYRAN-2-ONE (3 entities in total)
• 機能のキーワード: enzyme-inhibitor complex, transferase
• 由来する生物種: Hepatitis C virus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 64658.13

構造登録者

Love, R.A.,Parge, H.E.,Yu, X.,Hickey, M.J.,Diehl, W.,Gao, J.,Wriggers, H.,Ekker, A.,Wang, L.,Thomson, J.A.,Dragovich, P.S.,Fuhrman, S.A. (登録日: 2003-03-18, 公開日: 2004-03-18, 最終更新日: 2024-04-03)

• 主引用文献: Love, R.A.,Parge, H.E.,Yu, X.,Hickey, M.J.,Diehl, W.,Gao, J.,Wriggers, H.,Ekker, A.,Wang, L.,Thomson, J.A.,Dragovich, P.S.,Fuhrman, S.A.; Crystallographic identification of a noncompetitive inhibitor binding site on the hepatitis C virus NS5B RNA polymerase enzyme.; J.Virol., 77:7575-7581, 2003; PubMed: 12805457; DOI: 10.1128/JVI.77.13.7575-7581.2003

実験手法

X-RAY DIFFRACTION (2.2 Å)