1OS2

Ternary enzyme-product-inhibitor complexes of human MMP12

Summary for 1OS2

Entry DOI	10.2210/pdb1os2/pdb
Related	1JK3 1OS9
Descriptor	Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (7 entities in total)
Functional Keywords	matrix metalloproteinase, hydroxamic acid, mmp12, elastase, complex (elastase-inhibitor), metallo elastase, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space, extracellular matrix (Probable): P39900
Total number of polymer chains	6
Total formula weight	111847.38
Authors	Bertini, I.,Calderone, V.,Fragai, M.,Luchinat, C.,Mangani, S.,Terni, B. (deposition date: 2003-03-18, release date: 2003-08-05, Last modification date: 2023-08-16)
Primary citation	Bertini, I.,Calderone, V.,Fragai, M.,Luchinat, C.,Mangani, S.,Terni, B. X-ray Structures of Binary and Ternary Enzyme-Product-Inhibitor Complexes of Matrix Metalloproteinases Angew.Chem.Int.Ed.Engl., 42:2673-2676, 2003 Cited by PubMed: 12813751 DOI: 10.1002/anie.200350957 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation