Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1OS2

Ternary enzyme-product-inhibitor complexes of human MMP12

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0031012	cellular_component	extracellular matrix
B	0004222	molecular_function	metalloendopeptidase activity
B	0006508	biological_process	proteolysis
B	0008237	molecular_function	metallopeptidase activity
B	0008270	molecular_function	zinc ion binding
B	0031012	cellular_component	extracellular matrix
C	0004222	molecular_function	metalloendopeptidase activity
C	0006508	biological_process	proteolysis
C	0008237	molecular_function	metallopeptidase activity
C	0008270	molecular_function	zinc ion binding
C	0031012	cellular_component	extracellular matrix
D	0004222	molecular_function	metalloendopeptidase activity
D	0006508	biological_process	proteolysis
D	0008237	molecular_function	metallopeptidase activity
D	0008270	molecular_function	zinc ion binding
D	0031012	cellular_component	extracellular matrix
E	0004222	molecular_function	metalloendopeptidase activity
E	0006508	biological_process	proteolysis
E	0008237	molecular_function	metallopeptidase activity
E	0008270	molecular_function	zinc ion binding
E	0031012	cellular_component	extracellular matrix
F	0004222	molecular_function	metalloendopeptidase activity
F	0006508	biological_process	proteolysis
F	0008237	molecular_function	metallopeptidase activity
F	0008270	molecular_function	zinc ion binding
F	0031012	cellular_component	extracellular matrix

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 869

Chain	Residue
A	HIS218
A	HIS222
A	HIS228
A	HAE874

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 870

Chain	Residue
A	HIS168
A	ASP170
A	HIS183
A	HIS196

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 871

Chain	Residue
A	GLY176
A	GLY178
A	ILE180
A	ASP198
A	GLU201
A	ASP175

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 872

Chain	Residue
A	ASP158
A	GLY190
A	GLY192
A	ASP194

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA A 873

Chain	Residue
A	ASP124
A	GLU199
A	GLU201

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 369

Chain	Residue
B	HIS218
B	HIS222
B	HIS228
B	ACT374

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 370

Chain	Residue
B	HIS168
B	ASP170
B	HIS183
B	HIS196

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 371

Chain	Residue
B	ASP175
B	GLY176
B	GLY178
B	ILE180
B	ASP198
B	GLU201

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 372

Chain	Residue
B	ASP158
B	GLY190
B	GLY192
B	ASP194
B	HOH397

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 373

Chain	Residue
B	ASP124
B	GLU199
B	GLU201
B	HOH393
B	HOH430

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT B 374

Chain	Residue
A	MET104
B	HIS222
B	HIS228
B	ZN369
B	HOH434

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 469

Chain	Residue
B	MET104
C	HIS218
C	HIS222
C	HIS228
C	AZI474

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 470

Chain	Residue
C	HIS168
C	ASP170
C	HIS183
C	HIS196

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 471

Chain	Residue
C	ASP175
C	GLY176
C	GLY178
C	ILE180
C	ASP198
C	GLU201

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 472

Chain	Residue
C	ASP158
C	GLY190
C	GLY192
C	ASP194
C	HOH494
C	HOH520

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 473

Chain	Residue
A	HOH905
C	ASP124
C	GLU199
C	GLU201
C	HOH506

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE AZI C 474

Chain	Residue
B	MET104
C	HIS218
C	GLU219
C	HIS222
C	HIS228
C	ZN469

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 569

Chain	Residue
D	HIS218
D	HIS222
D	HIS228
D	HAE574

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 570

Chain	Residue
D	HIS168
D	ASP170
D	HIS183
D	HIS196

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 571

Chain	Residue
D	ASP175
D	GLY176
D	GLY178
D	ILE180
D	ASP198
D	GLU201

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA D 572

Chain	Residue
D	ASP194
D	HOH598
D	ASP158
D	GLY190
D	GLY192

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA D 573

Chain	Residue
D	ASP124
D	GLU199
D	GLU201

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 669

Chain	Residue
E	HIS218
E	HIS222
E	HIS228
E	ACT674

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 670

Chain	Residue
E	HIS168
E	ASP170
E	HIS183
E	HIS196

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 671

Chain	Residue
E	ASP175
E	GLY176
E	GLY178
E	ILE180
E	ASP198
E	GLU201

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA E 672

Chain	Residue
E	ASP158
E	GLY190
E	GLY192
E	ASP194

site_id	CC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA E 673

Chain	Residue
E	ASP124
E	GLU199
E	GLU201
E	HOH708

site_id	DC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ACT E 674

Chain	Residue
D	MET104
E	ALA182
E	HIS218
E	GLU219
E	HIS222
E	HIS228
E	ZN669
E	HOH722

site_id	DC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN F 769

Chain	Residue
E	MET104
F	HIS218
F	HIS222
F	HIS228
F	AZI774

site_id	DC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 770

Chain	Residue
F	HIS168
F	ASP170
F	HIS183
F	HIS196

site_id	DC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA F 771

Chain	Residue
F	ASP175
F	GLY176
F	GLY178
F	ILE180
F	ASP198
F	GLU201

site_id	DC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA F 772

Chain	Residue
F	ASP158
F	GLY190
F	GLY192
F	ASP194
F	HOH786
F	HOH812

site_id	DC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA F 773

Chain	Residue
F	ASP124
F	GLU199
F	GLU201
F	HOH802

site_id	DC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE AZI F 774

Chain	Residue
E	MET104
F	HIS218
F	HIS222
F	HIS228
F	ZN769

site_id	DC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE HAE A 874

Chain	Residue
A	ALA182
A	HIS183
A	HIS218
A	GLU219
A	HIS222
A	HIS228
A	ZN869
A	HOH894
A	HOH919
C	MET104

site_id	DC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE HAE D 574

Chain	Residue
D	ALA182
D	HIS183
D	HIS218
D	GLU219
D	HIS222
D	HIS228
D	ZN569
D	HOH586
D	HOH607
F	MET104

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAVHEIGHSL

Chain	Residue	Details
A	THR215-LEU224

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE:

Chain	Residue	Details
A	GLU219
B	GLU219
C	GLU219
D	GLU219
E	GLU219
F	GLU219

site_id	SWS_FT_FI2
Number of Residues	114
Details	BINDING:

Chain	Residue	Details
A	ASP124
A	GLY190
F	ASP175
F	GLY176
F	GLY178
F	ILE180
F	HIS183
F	GLY190
F	GLY192
F	ASP194
F	HIS196
F	ASP198
A	GLY192
F	GLU199
F	GLU201
F	HIS218
F	HIS222
F	HIS228
A	ASP194
A	HIS196
A	ASP198
A	GLU199
A	GLU201
A	HIS218
A	HIS222
A	HIS228
A	ASP158
B	ASP124
B	ASP158
B	HIS168
B	ASP170
B	ASP175
B	GLY176
B	GLY178
B	ILE180
B	HIS183
B	GLY190
A	HIS168
B	GLY192
B	ASP194
B	HIS196
B	ASP198
B	GLU199
B	GLU201
B	HIS218
B	HIS222
B	HIS228
C	ASP124
A	ASP170
C	ASP158
C	HIS168
C	ASP170
C	ASP175
C	GLY176
C	GLY178
C	ILE180
C	HIS183
C	GLY190
C	GLY192
A	ASP175
C	ASP194
C	HIS196
C	ASP198
C	GLU199
C	GLU201
C	HIS218
C	HIS222
C	HIS228
D	ASP124
D	ASP158
A	GLY176
D	HIS168
D	ASP170
D	ASP175
D	GLY176
D	GLY178
D	ILE180
D	HIS183
D	GLY190
D	GLY192
D	ASP194
A	GLY178
D	HIS196
D	ASP198
D	GLU199
D	GLU201
D	HIS218
D	HIS222
D	HIS228
E	ASP124
E	ASP158
E	HIS168
A	ILE180
E	ASP170
E	ASP175
E	GLY176
E	GLY178
E	ILE180
E	HIS183
E	GLY190
E	GLY192
E	ASP194
E	HIS196
A	HIS183
E	ASP198
E	GLU199
E	GLU201
E	HIS218
E	HIS222
E	HIS228
F	ASP124
F	ASP158
F	HIS168
F	ASP170

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
A	MET236
A	GLU219

site_id	CSA10
Number of Residues	1
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
D	GLU219

site_id	CSA11
Number of Residues	1
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
E	GLU219

site_id	CSA12
Number of Residues	1
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
F	GLU219

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
B	MET236
B	GLU219

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
C	MET236
C	GLU219

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
D	MET236
D	GLU219

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
E	MET236
E	GLU219

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
F	MET236
F	GLU219

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
A	GLU219

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
B	GLU219

site_id	CSA9
Number of Residues	1
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
C	GLU219

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)