1OS2
Ternary enzyme-product-inhibitor complexes of human MMP12
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004222 | molecular_function | metalloendopeptidase activity |
A | 0006508 | biological_process | proteolysis |
A | 0008237 | molecular_function | metallopeptidase activity |
A | 0008270 | molecular_function | zinc ion binding |
A | 0031012 | cellular_component | extracellular matrix |
B | 0004222 | molecular_function | metalloendopeptidase activity |
B | 0006508 | biological_process | proteolysis |
B | 0008237 | molecular_function | metallopeptidase activity |
B | 0008270 | molecular_function | zinc ion binding |
B | 0031012 | cellular_component | extracellular matrix |
C | 0004222 | molecular_function | metalloendopeptidase activity |
C | 0006508 | biological_process | proteolysis |
C | 0008237 | molecular_function | metallopeptidase activity |
C | 0008270 | molecular_function | zinc ion binding |
C | 0031012 | cellular_component | extracellular matrix |
D | 0004222 | molecular_function | metalloendopeptidase activity |
D | 0006508 | biological_process | proteolysis |
D | 0008237 | molecular_function | metallopeptidase activity |
D | 0008270 | molecular_function | zinc ion binding |
D | 0031012 | cellular_component | extracellular matrix |
E | 0004222 | molecular_function | metalloendopeptidase activity |
E | 0006508 | biological_process | proteolysis |
E | 0008237 | molecular_function | metallopeptidase activity |
E | 0008270 | molecular_function | zinc ion binding |
E | 0031012 | cellular_component | extracellular matrix |
F | 0004222 | molecular_function | metalloendopeptidase activity |
F | 0006508 | biological_process | proteolysis |
F | 0008237 | molecular_function | metallopeptidase activity |
F | 0008270 | molecular_function | zinc ion binding |
F | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 869 |
Chain | Residue |
A | HIS218 |
A | HIS222 |
A | HIS228 |
A | HAE874 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 870 |
Chain | Residue |
A | HIS168 |
A | ASP170 |
A | HIS183 |
A | HIS196 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 871 |
Chain | Residue |
A | GLY176 |
A | GLY178 |
A | ILE180 |
A | ASP198 |
A | GLU201 |
A | ASP175 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CA A 872 |
Chain | Residue |
A | ASP158 |
A | GLY190 |
A | GLY192 |
A | ASP194 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CA A 873 |
Chain | Residue |
A | ASP124 |
A | GLU199 |
A | GLU201 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 369 |
Chain | Residue |
B | HIS218 |
B | HIS222 |
B | HIS228 |
B | ACT374 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 370 |
Chain | Residue |
B | HIS168 |
B | ASP170 |
B | HIS183 |
B | HIS196 |
site_id | AC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA B 371 |
Chain | Residue |
B | ASP175 |
B | GLY176 |
B | GLY178 |
B | ILE180 |
B | ASP198 |
B | GLU201 |
site_id | AC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CA B 372 |
Chain | Residue |
B | ASP158 |
B | GLY190 |
B | GLY192 |
B | ASP194 |
B | HOH397 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CA B 373 |
Chain | Residue |
B | ASP124 |
B | GLU199 |
B | GLU201 |
B | HOH393 |
B | HOH430 |
site_id | BC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ACT B 374 |
Chain | Residue |
A | MET104 |
B | HIS222 |
B | HIS228 |
B | ZN369 |
B | HOH434 |
site_id | BC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN C 469 |
Chain | Residue |
B | MET104 |
C | HIS218 |
C | HIS222 |
C | HIS228 |
C | AZI474 |
site_id | BC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C 470 |
Chain | Residue |
C | HIS168 |
C | ASP170 |
C | HIS183 |
C | HIS196 |
site_id | BC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA C 471 |
Chain | Residue |
C | ASP175 |
C | GLY176 |
C | GLY178 |
C | ILE180 |
C | ASP198 |
C | GLU201 |
site_id | BC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA C 472 |
Chain | Residue |
C | ASP158 |
C | GLY190 |
C | GLY192 |
C | ASP194 |
C | HOH494 |
C | HOH520 |
site_id | BC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CA C 473 |
Chain | Residue |
A | HOH905 |
C | ASP124 |
C | GLU199 |
C | GLU201 |
C | HOH506 |
site_id | BC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE AZI C 474 |
Chain | Residue |
B | MET104 |
C | HIS218 |
C | GLU219 |
C | HIS222 |
C | HIS228 |
C | ZN469 |
site_id | BC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN D 569 |
Chain | Residue |
D | HIS218 |
D | HIS222 |
D | HIS228 |
D | HAE574 |
site_id | CC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN D 570 |
Chain | Residue |
D | HIS168 |
D | ASP170 |
D | HIS183 |
D | HIS196 |
site_id | CC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA D 571 |
Chain | Residue |
D | ASP175 |
D | GLY176 |
D | GLY178 |
D | ILE180 |
D | ASP198 |
D | GLU201 |
site_id | CC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CA D 572 |
Chain | Residue |
D | ASP194 |
D | HOH598 |
D | ASP158 |
D | GLY190 |
D | GLY192 |
site_id | CC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CA D 573 |
Chain | Residue |
D | ASP124 |
D | GLU199 |
D | GLU201 |
site_id | CC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN E 669 |
Chain | Residue |
E | HIS218 |
E | HIS222 |
E | HIS228 |
E | ACT674 |
site_id | CC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN E 670 |
Chain | Residue |
E | HIS168 |
E | ASP170 |
E | HIS183 |
E | HIS196 |
site_id | CC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA E 671 |
Chain | Residue |
E | ASP175 |
E | GLY176 |
E | GLY178 |
E | ILE180 |
E | ASP198 |
E | GLU201 |
site_id | CC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CA E 672 |
Chain | Residue |
E | ASP158 |
E | GLY190 |
E | GLY192 |
E | ASP194 |
site_id | CC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CA E 673 |
Chain | Residue |
E | ASP124 |
E | GLU199 |
E | GLU201 |
E | HOH708 |
site_id | DC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE ACT E 674 |
Chain | Residue |
D | MET104 |
E | ALA182 |
E | HIS218 |
E | GLU219 |
E | HIS222 |
E | HIS228 |
E | ZN669 |
E | HOH722 |
site_id | DC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN F 769 |
Chain | Residue |
E | MET104 |
F | HIS218 |
F | HIS222 |
F | HIS228 |
F | AZI774 |
site_id | DC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN F 770 |
Chain | Residue |
F | HIS168 |
F | ASP170 |
F | HIS183 |
F | HIS196 |
site_id | DC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA F 771 |
Chain | Residue |
F | ASP175 |
F | GLY176 |
F | GLY178 |
F | ILE180 |
F | ASP198 |
F | GLU201 |
site_id | DC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA F 772 |
Chain | Residue |
F | ASP158 |
F | GLY190 |
F | GLY192 |
F | ASP194 |
F | HOH786 |
F | HOH812 |
site_id | DC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CA F 773 |
Chain | Residue |
F | ASP124 |
F | GLU199 |
F | GLU201 |
F | HOH802 |
site_id | DC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE AZI F 774 |
Chain | Residue |
E | MET104 |
F | HIS218 |
F | HIS222 |
F | HIS228 |
F | ZN769 |
site_id | DC8 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE HAE A 874 |
Chain | Residue |
A | ALA182 |
A | HIS183 |
A | HIS218 |
A | GLU219 |
A | HIS222 |
A | HIS228 |
A | ZN869 |
A | HOH894 |
A | HOH919 |
C | MET104 |
site_id | DC9 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE HAE D 574 |
Chain | Residue |
D | ALA182 |
D | HIS183 |
D | HIS218 |
D | GLU219 |
D | HIS222 |
D | HIS228 |
D | ZN569 |
D | HOH586 |
D | HOH607 |
F | MET104 |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAVHEIGHSL |
Chain | Residue | Details |
A | THR215-LEU224 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | ACT_SITE: |
Chain | Residue | Details |
A | GLU219 | |
B | GLU219 | |
C | GLU219 | |
D | GLU219 | |
E | GLU219 | |
F | GLU219 |
site_id | SWS_FT_FI2 |
Number of Residues | 114 |
Details | BINDING: |
Chain | Residue | Details |
A | ASP124 | |
A | GLY190 | |
F | ASP175 | |
F | GLY176 | |
F | GLY178 | |
F | ILE180 | |
F | HIS183 | |
F | GLY190 | |
F | GLY192 | |
F | ASP194 | |
F | HIS196 | |
F | ASP198 | |
A | GLY192 | |
F | GLU199 | |
F | GLU201 | |
F | HIS218 | |
F | HIS222 | |
F | HIS228 | |
A | ASP194 | |
A | HIS196 | |
A | ASP198 | |
A | GLU199 | |
A | GLU201 | |
A | HIS218 | |
A | HIS222 | |
A | HIS228 | |
A | ASP158 | |
B | ASP124 | |
B | ASP158 | |
B | HIS168 | |
B | ASP170 | |
B | ASP175 | |
B | GLY176 | |
B | GLY178 | |
B | ILE180 | |
B | HIS183 | |
B | GLY190 | |
A | HIS168 | |
B | GLY192 | |
B | ASP194 | |
B | HIS196 | |
B | ASP198 | |
B | GLU199 | |
B | GLU201 | |
B | HIS218 | |
B | HIS222 | |
B | HIS228 | |
C | ASP124 | |
A | ASP170 | |
C | ASP158 | |
C | HIS168 | |
C | ASP170 | |
C | ASP175 | |
C | GLY176 | |
C | GLY178 | |
C | ILE180 | |
C | HIS183 | |
C | GLY190 | |
C | GLY192 | |
A | ASP175 | |
C | ASP194 | |
C | HIS196 | |
C | ASP198 | |
C | GLU199 | |
C | GLU201 | |
C | HIS218 | |
C | HIS222 | |
C | HIS228 | |
D | ASP124 | |
D | ASP158 | |
A | GLY176 | |
D | HIS168 | |
D | ASP170 | |
D | ASP175 | |
D | GLY176 | |
D | GLY178 | |
D | ILE180 | |
D | HIS183 | |
D | GLY190 | |
D | GLY192 | |
D | ASP194 | |
A | GLY178 | |
D | HIS196 | |
D | ASP198 | |
D | GLU199 | |
D | GLU201 | |
D | HIS218 | |
D | HIS222 | |
D | HIS228 | |
E | ASP124 | |
E | ASP158 | |
E | HIS168 | |
A | ILE180 | |
E | ASP170 | |
E | ASP175 | |
E | GLY176 | |
E | GLY178 | |
E | ILE180 | |
E | HIS183 | |
E | GLY190 | |
E | GLY192 | |
E | ASP194 | |
E | HIS196 | |
A | HIS183 | |
E | ASP198 | |
E | GLU199 | |
E | GLU201 | |
E | HIS218 | |
E | HIS222 | |
E | HIS228 | |
F | ASP124 | |
F | ASP158 | |
F | HIS168 | |
F | ASP170 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
A | MET236 | |
A | GLU219 |
site_id | CSA10 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
D | GLU219 |
site_id | CSA11 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
E | GLU219 |
site_id | CSA12 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
F | GLU219 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
B | MET236 | |
B | GLU219 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
C | MET236 | |
C | GLU219 |
site_id | CSA4 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
D | MET236 | |
D | GLU219 |
site_id | CSA5 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
E | MET236 | |
E | GLU219 |
site_id | CSA6 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
F | MET236 | |
F | GLU219 |
site_id | CSA7 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
A | GLU219 |
site_id | CSA8 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
B | GLU219 |
site_id | CSA9 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
C | GLU219 |