1OS2
Ternary enzyme-product-inhibitor complexes of human MMP12
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... | Macrophage metalloelastase | polymer | 165 | 18331.5 | 6 | UniProt (P39900) Pfam (PF00413) In PDB | Homo sapiens (human) | HME, Matrix metalloproteinase-12, MMP-12, Macrophage elastase, ME |
| 2 | E, A, F, B, C... | ZINC ION | non-polymer | 65.4 | 12 | Chemie (ZN) | |||
| 3 | D, E, A, F, B... | CALCIUM ION | non-polymer | 40.1 | 18 | Chemie (CA) | |||
| 4 | D, A | ACETOHYDROXAMIC ACID | non-polymer | 75.1 | 2 | Chemie (HAE) | |||
| 5 | E, B | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 6 | F, C | AZIDE ION | non-polymer | 42.0 | 2 | Chemie (AZI) | |||
| 7 | water | water | 18.0 | 308 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 106 - 268 (UniProt: P39900)
| PDB | External Database | Details |
|---|---|---|
| Met 104 | - | cloning artifact |
| Met 105 | - | cloning artifact |
| Asp 171 | Phe 171 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 109988.8 | |
| Non-Polymers* | Number of molecules | 36 |
| Total formula weight | 1858.6 | |
| All* | Total formula weight | 111847.4 |
