1ORF
The Oligomeric Structure of Human Granzyme A Reveals the Molecular Determinants of Substrate Specificity
Summary for 1ORF
Entry DOI | 10.2210/pdb1orf/pdb |
Related PRD ID | PRD_000020 |
Descriptor | Granzyme A, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Isoform alpha: Secreted: P12544 |
Total number of polymer chains | 1 |
Total formula weight | 26420.11 |
Authors | Bell, J.K.,Goetz, D.H.,Mahrus, S.,Harris, J.L.,Fletterick, R.J.,Craik, C.S. (deposition date: 2003-03-12, release date: 2003-07-01, Last modification date: 2024-03-13) |
Primary citation | Bell, J.K.,Goetz, D.H.,Mahrus, S.,Harris, J.L.,Fletterick, R.J.,Craik, C.S. The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity. Nat.Struct.Biol., 10:527-534, 2003 Cited by PubMed: 12819769DOI: 10.1038/nsb944 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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