1ONQ

Crystal Structure of CD1a in Complex with a Sulfatide

1ONQ の概要

• エントリーDOI: 10.2210/pdb1onq/pdb
• 関連するPDBエントリー: 1CD1 1GZP 1GZQ
• 分子名称: T-cell surface glycoprotein CD1a, Beta-2-microglobulin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: protein-glycolipid complex, beta sheet platform, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 92323.52

構造登録者

Zajonc, D.M.,Elsliger, M.A.,Teyton, L.,Wilson, I.A. (登録日: 2003-02-28, 公開日: 2003-08-05, 最終更新日: 2024-11-20)

主引用文献

Zajonc, D.M.,Elsliger, M.A.,Teyton, L.,Wilson, I.A.
Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A.
Nat.Immunol., 4:808-815, 2003

PubMed Abstract: CD1 antigens bind a variety of self and foreign lipid and glycolipid antigens for presentation to CD1-restricted T cell receptors (TCRs). Here we report the crystal structure of human CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A. The lipid adopts an S-shaped conformation, with the sphingosine chain completely buried in the A' pocket and the fatty acid chain emerging from the interface of the A' pocket into the more exposed F' pocket. The headgroup is anchored in the A'-F' junction and protrudes into the F' pocket for TCR recognition. Because the A' pocket is narrow with a fixed terminus, it can act as a molecular 'ruler' to select alkyl chains of a particular length.

PubMed: 12833155
DOI: 10.1038/ni948

実験手法

X-RAY DIFFRACTION (2.15 Å)