1OIA

U1A rnp domain 1-95

「1NRC」から置き換えられました

1OIA の概要

• エントリーDOI: 10.2210/pdb1oia/pdb
• 関連するPDBエントリー: 1AUD 1CX0 1DRZ 1DZ5 1FHT 1M5K 1M5O 1M5P 1M5V 1NU4 1URN 2U1A 3UTR
• 分子名称: U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A (2 entities in total)
• 機能のキーワード: ribonucleoprotein, nuclear protein, rna-binding
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Nucleus: P09012
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 21893.44

構造登録者

Nagai, K.,Evans, P.R. (登録日: 2003-06-12, 公開日: 2003-06-26, 最終更新日: 2024-05-08)

主引用文献

Nagai, K.,Oubridge, C.,Jessen, T.H.,Li, J.,Evans, P.R.
Crystal Structure of the RNA-Binding Domain of the U1 Small Nuclear Ribonucleoprotein A
Nature, 348:515-, 1990

PubMed Abstract: The crystal structure of the RNA binding domain of the U1 small nuclear ribonucleoprotein A, which forms part of the ribonucleoprotein complex involved in the excision of introns, has been solved. It contains a four-stranded beta sheet and two alpha helices. The highly conserved segments designated RNP1 and RNP2 lie side by side on the middle two beta strands. U1 RNA binding studies of mutant proteins suggest that the RNA binds to the four-stranded beta sheet and to the flexible loops on one end.

PubMed: 2147232
DOI: 10.1038/348515A0

実験手法

X-RAY DIFFRACTION (2.4 Å)