1OHY
4-AMINOBUTYRATE-AMINOTRANSFERASE inactivated by gamma-ethynyl GABA
Summary for 1OHY
Entry DOI | 10.2210/pdb1ohy/pdb |
Related | 1OHV 1OHW |
Descriptor | 4-AMINOBUTYRATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE, (4E)-4-AMINOHEX-4-ENOIC ACID, ... (5 entities in total) |
Functional Keywords | transferase, plp-dependent enzyme, aminotransferase, 4- aminobutyric acid, antiepileptic drug target, vigabatrin pyridoxal phosphate, neurotransmitter degradation, mitochondrion, transit peptide |
Biological source | SUS SCROFA (PIG) |
Cellular location | Mitochondrion matrix: P80147 |
Total number of polymer chains | 4 |
Total formula weight | 215332.82 |
Authors | Storici, P.,Schirmer, T. (deposition date: 2003-06-03, release date: 2003-10-16, Last modification date: 2011-07-13) |
Primary citation | Storici, P.,De Biase, D.,Bossa, F.,Bruno, S.,Mozzarelli, A.,Peneff, C.,Silverman, R.,Schirmer, T. Structures of {Gamma}-Aminobutyric Acid (Gaba) Aminotransferase, a Pyridoxal 5'-Phosphate, and [2Fe-2S] Cluster-Containing Enzyme, Complexed with {Gamma}-Ethynyl-Gaba and with the Antiepilepsy Drug Vigabatrin J.Biol.Chem., 279:363-, 2004 Cited by PubMed: 14534310DOI: 10.1074/JBC.M305884200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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