1O5M

Structure of FPT bound to the inhibitor SCH66336

1O5M の概要

• エントリーDOI: 10.2210/pdb1o5m/pdb
• 関連するPDBエントリー: 1QBQ
• 分子名称: Protein farnesyltransferase alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ... (6 entities in total)
• 機能のキーワード: protein inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 93894.93

構造登録者

Strickland, C.L.,Weber, P.C.,Ganguly, A.K. (登録日: 2003-09-26, 公開日: 2003-10-21, 最終更新日: 2023-12-27)

• 主引用文献: Strickland, C.L.,Weber, P.C.,Windsor, W.T.,Wu, Z.,Le, H.V.,Albanese, M.M.,Alvarez, C.S.,Cesarz, D.,del Rosario, J.,Deskus, J.,Mallams, A.K.,Njoroge, F.G.,Piwinski, J.J.,Remiszewski, S.,Rossman, R.R.,Taveras, A.G.,Vibulbhan, B.,Doll, R.J.,Girijavallabhan, V.M.,Ganguly, A.K.; Tricyclic Farnesyl Protein Transferase Inhibitors: Crystallographic and Calorimetric Studies of Structure-Activity Relationships; J.Med.Chem., 42:2125-2135, 1999; PubMed: 10377218; DOI: 10.1021/jm990030g

実験手法

X-RAY DIFFRACTION (2.3 Å)