1O23

CRYSTAL STRUCTURE OF LACTOSE SYNTHASE IN THE PRESENCE OF UDP-GLUCOSE

Replaces:  1NT7

Summary for 1O23

DescriptorALPHA-LACTALBUMIN, BETA-1,4-GALACTOSYLTRANSFERASE, CALCIUM ION, ... (9 entities in total)
Functional Keywords1, alpha-lactalbumin; beta, 4-galactosyltransferase; udp-glucose, transferase activator-transferase complex, transferase activator/transferase
Biological sourceMus musculus (house mouse)
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Cellular locationSecreted P29752
Isoform Long: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Isoform Short: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Processed beta-1,4-galactosyltransferase 1: Secreted P08037
Total number of polymer chains4
Total molecular weight96449.55
Authors
Ramakrishnan, B.,Shah, P.S.,Qasba, P.K. (deposition date: 2003-01-29, release date: 2003-02-25, Last modification date: 2013-05-08)
Primary citation
Ramakrishnan, B.,Shah, P.S.,Qasba, P.K.
Alpha-Lactalbumin (La) Stimulates Milk Beta-1,4-Galactosyltransferase I (Beta 4Gal-T1) to Transfer Glucose from Udp-Glucose to N-Acetylglucosamine. Crystal Structure of Beta 4Gal-T1 X La Complex with Udp-Glc.
J.Biol.Chem., 276:37665-37671, 2001
PubMed: 11485999 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M102458200
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.32 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.260170.1%6.1%3.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (1o23.pdb2.gz [73.36 KB])
Coordinate files for Biological unit (1o23.pdb1.gz [73.71 KB])