1NZ7
POTENT, SELECTIVE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B USING A SECOND PHOSPHOTYROSINE BINDING SITE, complexed with compound 19.
Summary for 1NZ7
Entry DOI | 10.2210/pdb1nz7/pdb |
Related | 1NL9 1NNY 1No6 1ONY 1ONZ |
Descriptor | Protein-tyrosine phosphatase, non-receptor type 1, 2-[(4-{2-ACETYLAMINO-2-[4-(1-CARBOXY-3-METHYLSULFANYL-PROPYLCARBAMOYL)-BUTYLCARBAMOYL]-ETHYL}-2-ETHYL-PHENYL)-OXALYL-AM INO]-BENZOIC ACID (3 entities in total) |
Functional Keywords | protein tyrosine phosphatase fold, oxamic acid inhibitor bound to p-loop, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031 |
Total number of polymer chains | 1 |
Total formula weight | 38038.38 |
Authors | Xin, Z.,Oost, T.K.,Abad-Zapatero, C.,Hajduk, P.J.,Pei, Z.,Szczepankiewicz, B.G.,Hutchins, C.W.,Ballaron, S.J.,Stashko, M.A.,Lubben, T.,Trevillyan, J.M.,Jirousek, M.R.,Liu, G. (deposition date: 2003-02-16, release date: 2003-05-20, Last modification date: 2023-08-16) |
Primary citation | Xin, Z.,Oost, T.K.,Abad-Zapatero, C.,Hajduk, P.J.,Pei, Z.,Szczepankiewicz, B.G.,Hutchins, C.W.,Ballaron, S.J.,Stashko, M.A.,Lubben, T.,Trevillyan, J.M.,Jirousek, M.R.,Liu, G. Potent, Selective Inhibitors of Protein Tyrosine Phosphatase 1B BIOORG.MED.CHEM.LETT., 13:1887-1890, 2003 Cited by PubMed: 12749891DOI: 10.1016/S0960-894X(03)00302-0 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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