1NXK

Crystal structure of staurosporine bound to MAP KAP kinase 2

1NXK の概要

• エントリーDOI: 10.2210/pdb1nxk/pdb
• 分子名称: MAP kinase-activated protein kinase 2, STAUROSPORINE, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: protein kinase, mk2, phosphorylation, staurosporine, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 186828.14

構造登録者

Underwood, K.W.,Parris, K.D.,Federico, E.,Mosyak, L.,Czerwinski, R.M.,Shane, T.,Taylor, M.,Svenson, K.,Liu, Y.,Hsiao, C.L.,Wolfrom, S.,Malakian, K.,Telliez, J.B.,Lin, L.L.,Kriz, R.W.,Seehra, J.,Somers, W.S.,Stahl, M.L. (登録日: 2003-02-10, 公開日: 2003-10-14, 最終更新日: 2011-07-13)

• 主引用文献: Underwood, K.W.,Parris, K.D.,Federico, E.,Mosyak, L.,Czerwinski, R.M.,Shane, T.,Taylor, M.,Svenson, K.,Liu, Y.,Hsiao, C.L.,Wolfrom, S.,Maguire, M.,Malakian, K.,Telliez, J.B.,Lin, L.L.,Kriz, R.W.,Seehra, J.,Somers, W.S.,Stahl, M.L.; Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme; Structure, 11:627-636, 2003; PubMed: 12791252; DOI: 10.1016/S0969-2126(03)00092-3

実験手法

X-RAY DIFFRACTION (2.7 Å)