1NOP

Crystal structure of human tyrosyl-DNA phosphodiesterase (Tdp1) in complex with vanadate, DNA and a human topoisomerase I-derived peptide

Summary for 1NOP

• Entry DOI: 10.2210/pdb1nop/pdb
• Related: 1JY1 1MU7 1MU9
• Descriptor: 5'-D(*AP*GP*AP*GP*TP*T)-3', tyrosyl-DNA phosphodiesterase 1, topoisomerase I-derived peptide, ... (5 entities in total)
• Functional Keywords: protein-dna complex, vanadate complex, transition state mimic, hydrolase-dna complex, hydrolase/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 114408.96

Authors

Davies, D.R.,Interthal, H.,Champoux, J.J.,Hol, W.G.J. (deposition date: 2003-01-16, release date: 2003-03-11, Last modification date: 2024-02-14)

• Primary citation: Davies, D.R.,Interthal, H.,Champoux, J.J.,Hol, W.G.J.; Crystal structure of a transition state mimic for Tdp1 assembled from vanadate, DNA, and a topoisomerase I-derived peptide; Chem.Biol., 10:139-147, 2003; PubMed: 12618186; DOI: 10.1016/S1074-5521(03)00021-8

Experimental method

X-RAY DIFFRACTION (2.3 Å)