1NOP

Crystal structure of human tyrosyl-DNA phosphodiesterase (Tdp1) in complex with vanadate, DNA and a human topoisomerase I-derived peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0006281	biological_process	DNA repair
A	0008081	molecular_function	phosphoric diester hydrolase activity
B	0005634	cellular_component	nucleus
B	0006281	biological_process	DNA repair
B	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE VO4 A 699

Chain	Residue
A	HIS263
A	LYS265
A	ASN283
A	HIS493
A	LYS495
A	ASN516
A	HOH728
C	TYR723
D	DT806

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site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE VO4 B 699

Chain	Residue
B	TYR204
B	HIS263
B	LYS265
B	ASN283
B	HIS493
B	LYS495
B	ASN516
F	DT806

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:12470949, ECO:0000269|PubMed:15111055

Chain	Residue	Details
A	HIS263
B	HIS263

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:12470949, ECO:0000269|PubMed:15111055

Chain	Residue	Details
A	HIS493
B	HIS493

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site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:12470949

Chain	Residue	Details
A	LYS265
A	LYS495
B	LYS265
B	LYS495

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Interaction with DNA => ECO:0000269|PubMed:12470949

Chain	Residue	Details
A	SER518
B	SER518

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