1NO9

Design of weakly basic thrombin inhibitors incorporating novel P1 binding functions: molecular and X-ray crystallographic studies.

Summary for 1NO9
Related1HAH
DescriptorAlpha Thrombin, hirugen, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywordscomplex (serine protease-inhibitor), blood coagulation, serine proteinase inhibition, n, n-diphenylcarbamoyl-aminoguanidine, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
More
Total number of polymer chains3
Total formula weight35858.79
Authors
De Simone, G.,Menchise, V.,Omaggio, S.,Pedone, C.,Scozzafava, A.,Supuran, C.T. (deposition date: 2003-01-16, release date: 2003-08-26, Last modification date: 2020-07-29)
Primary citationDe Simone, G.,Menchise, V.,Omaggio, S.,Pedone, C.,Scozzafava, A.,Supuran, C.T.
DESIGN OF WEAKLY BASIC THROMBIN INHIBITORS INCORPORATING NOVEL P1 BINDING FUNCTIONS: MOLECULAR AND X-RAY CRYSTALLOGRAPHIC STUDIES
Biochemistry, 42:9013-9021, 2003
PubMed: 12885234
DOI: 110.1021/bi020512l
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation
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179210

PDB entries from 2021-06-23