1NO9
Design of weakly basic thrombin inhibitors incorporating novel P1 binding functions: molecular and X-ray crystallographic studies.
Summary for 1NO9
| Entry DOI | 10.2210/pdb1no9/pdb |
| Related | 1HAH |
| Descriptor | Alpha Thrombin, hirugen, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
| Functional Keywords | complex (serine protease-inhibitor), blood coagulation, serine proteinase inhibition, n, n-diphenylcarbamoyl-aminoguanidine, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 3 |
| Total formula weight | 35858.79 |
| Authors | De Simone, G.,Menchise, V.,Omaggio, S.,Pedone, C.,Scozzafava, A.,Supuran, C.T. (deposition date: 2003-01-16, release date: 2003-08-26, Last modification date: 2023-11-15) |
| Primary citation | De Simone, G.,Menchise, V.,Omaggio, S.,Pedone, C.,Scozzafava, A.,Supuran, C.T. DESIGN OF WEAKLY BASIC THROMBIN INHIBITORS INCORPORATING NOVEL P1 BINDING FUNCTIONS: MOLECULAR AND X-RAY CRYSTALLOGRAPHIC STUDIES Biochemistry, 42:9013-9021, 2003 Cited by PubMed: 12885234DOI: 10.1021/bi020512l PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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