1NJS

human GAR Tfase in complex with hydrolyzed form of 10-trifluoroacetyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid

Summary for 1NJS

• Entry DOI: 10.2210/pdb1njs/pdb
• Related: 1MEJ 1MEN 1MEO
• Descriptor: Phosphoribosylglycinamide formyltransferase, PHOSPHATE ION, N-{4-[(1R)-4-[(2R,4R,5S)-2,4-DIAMINO-6-OXOHEXAHYDROPYRIMIDIN-5-YL]-1-(2,2,2-TRIFLUORO-1,1-DIHYDROXYETHYL)BUTYL]BENZOYL}-D-GLUTAMIC ACID, ... (4 entities in total)
• Functional Keywords: protein-cofactor analogue complex, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 46741.79

Authors

Zhang, Y.,Desharnais, J.,Marsilje, T.H.,Li, C.,Hedrick, M.P.,Gooljarsingh, L.T.,Tavassoli, A.,Benkovic, S.J.,Olson, A.J.,Boger, D.L.,Wilson, I.A. (deposition date: 2003-01-02, release date: 2003-06-10, Last modification date: 2023-08-16)

• Primary citation: Zhang, Y.,Desharnais, J.,Marsilje, T.H.,Li, C.,Hedrick, M.P.,Gooljarsingh, L.T.,Tavassoli, A.,Benkovic, S.J.,Olson, A.J.,Boger, D.L.,Wilson, I.A.; Rational Design, Synthesis, Evaluation, and Crystal Structure of a Potent Inhibitor of Human GAR Tfase: 10-(Trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic Acid; Biochemistry, 42:6043-6056, 2003; PubMed: 12755606; DOI: 10.1021/bi034219c

Experimental method

X-RAY DIFFRACTION (1.98 Å)