1NI4

HUMAN PYRUVATE DEHYDROGENASE

1NI4 の概要

• エントリーDOI: 10.2210/pdb1ni4/pdb
• 分子名称: Pyruvate dehydrogenase E1 component: Alpha subunit, Pyruvate dehydrogenase E1 component: Beta subunit, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: thiamin pyrophosphate, pyruvate, alpha-keto acid dehydrogenase, pyruvate dehydrogenase, oxidoreductase
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Mitochondrion matrix: P08559 P11177
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 159444.81

構造登録者

Ciszak, E.,Korotchkina, L.G.,Dominiak, P.M.,Sidhu, S.,Patel, M.S. (登録日: 2002-12-20, 公開日: 2003-06-17, 最終更新日: 2011-07-13)

• 主引用文献: Ciszak, E.M.,Korotchkina, L.G.,Dominiak, P.M.,Sidhu, S.,Patel, M.S.; Structural Basis for Flip-Flop Action of Thiamin Pyrophosphate-Dependent Enzymes Revealed by Human Pyruvate Dehydrogenase; J.Biol.Chem., 278:21240-21246, 2003; PubMed: 12651851; DOI: 10.1074/jbc.M300339200

実験手法

X-RAY DIFFRACTION (1.95 Å)