1NHZ
Crystal Structure of the Antagonist Form of Glucocorticoid Receptor
Summary for 1NHZ
Entry DOI | 10.2210/pdb1nhz/pdb |
Descriptor | GLUCOCORTICOID RECEPTOR, 11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE, HEXANE-1,6-DIOL, ... (4 entities in total) |
Functional Keywords | protein-ligand complex, anti parallel alpha helix sandwich, hormone receptor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 32939.19 |
Authors | Kauppi, B.,Jakob, C.,Farnegardh, M.,Yang, J.,Ahola, H.,Alarcon, M.,Calles, K.,Engstrom, O.,Harlan, J.,Muchmore, S.,Ramqvist, A.-K.,Thorell, S.,Ohman, L.,Greer, J.,Gustafsson, J.-A.,Carlstedt-Duke, J.,Carlquist, M. (deposition date: 2002-12-20, release date: 2003-05-06, Last modification date: 2024-02-14) |
Primary citation | Kauppi, B.,Jakob, C.,Farnegardh, M.,Yang, J.,Ahola, H.,Alarcon, M.,Calles, K.,Engstrom, O.,Harlan, J.,Muchmore, S.,Ramqvist, A.-K.,Thorell, S.,Ohman, L.,Greer, J.,Gustafsson, J.-A.,Carlstedt-Duke, J.,Carlquist, M. The Three-dimensional Structures of Antagonistic and Agonistic Forms of the Glucocorticoid Receptor Ligand-binding Domain: RU-486 INDUCES A TRANSCONFORMATION THAT LEADS TO ACTIVE ANTAGONISM. J.Biol.Chem., 278:22748-22754, 2003 Cited by PubMed: 12686538DOI: 10.1074/jbc.M212711200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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