1NH3

Human Topoisomerase I Ara-C Complex

Summary for 1NH3

• Entry DOI: 10.2210/pdb1nh3/pdb
• Related: 1A31 1EJ9 1K4T 1LPQ
• Descriptor: 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*UP*(UBB))-3', 5'-D(*(GNG)P*GP*AP*AP*AP*AP*AP*UP*UP*UP*UP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*UP*UP*UP*UP*CP*(CAR)P*AP*AP*GP*UP*CP*UP*UP*UP*UP*T)-3', ... (5 entities in total)
• Functional Keywords: ara-c, protein-dna complex, dna damage, isomerase, isomerase-dna complex, isomerase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus, nucleolus: P11387
• Total number of polymer chains: 4
• Total formula weight: 79895.37

Authors

Chrencik, J.E.,Burgin, A.B.,Pommier, Y.,Stewart, L.,Redinbo, M.R. (deposition date: 2002-12-18, release date: 2003-03-04, Last modification date: 2023-11-15)

• Primary citation: Chrencik, J.E.,Burgin, A.B.,Pommier, Y.,Stewart, L.,Redinbo, M.R.; Structural Impact of the Leukemia Drug 1-beta-D-Arabinofuranosylcytosine (Ara-C) on the Covalent Human Topoisomerase I-DNA Complex; J.Biol.Chem., 278:12461-12466, 2003; PubMed: 12533542; DOI: 10.1074/jbc.M212930200

Experimental method

X-RAY DIFFRACTION (3.1 Å)