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1NH3

Human Topoisomerase I Ara-C Complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0003917molecular_functionDNA topoisomerase type I (single strand cut, ATP-independent) activity
A0005694cellular_componentchromosome
A0006265biological_processDNA topological change
Functional Information from PROSITE/UniProt
site_idPS00176
Number of Residues19
DetailsTOPO_IB_1 Topoisomerase (Topo) IB-type active site signature. EnkqialGTSKlnYLdprI
ChainResidueDetails
AGLU710-ILE728

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsRegion: {"description":"Interaction with DNA"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsActive site: {"description":"O-(3'-phospho-DNA)-tyrosine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU01382","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10130","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10841763","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12426403","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12533542","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15165849","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15801827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16033260","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9488644","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues7
DetailsSite: {"description":"Interaction with DNA"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by CK2","evidences":[{"source":"PubMed","id":"23185622","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues3
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1k4t
ChainResidueDetails
AARG488
AARG590

243531

PDB entries from 2025-10-22

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